Clinical Studies
TESTED BY ATHLETES. PROVEN BY SCIENCE.
Levagen® and Levagen®+ are the only branded palmitoylethanolamides in the industry with gold-standard clinical studies. Tested on various populations, Levagen® and Levagen®+ are clinically proven to:
Reduce joint pain and stiffness
Reduce anxiety
Delay fatigue Reduce muscle damage Stimulate muscle growth Improve recovery
Levagen®+ vs Standard PEA
Levagen®+ demonstrated 175.5% greater increase in levels of PEA in the body compared to standard PEA. Rapid absorption and action was seen with levels peaking 45 minutes post-ingestion.
Rao, Amanda, Alistair Mallard and David Briskey. “Increased absorption of Palmitoylethanolamide using a Novel Dispersion Technology System (LipiSperse®)” Journal of Nutraceuticals and Food Science (2019)
Supporting Joint Health with Levagen®
Joint pain affects various individuals, whether an active senior or elite athlete, which leads to decreased quality of life, reduced performance and immobility.*
Levagen® has been proven to improve symptoms of joint pain, stiffness and function dose-dependently over the course of 8 weeks.*
Palmitoylethanolamide is both a powerful anti-inflammatory and pain reliever, providing an all-in-one solution for managing discomfort.*
Steels, Elizabeth. et al. “A double-blind” randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis.” Inflammopharmacology 27.3 (2019): 475 – 485
Relax with Levagen®
Work, family and environment can take its toll at times and the need to relax is of vital importance when wanting to cope with day-to-day stressors.
Supplementing with Levagen® has been found to significantly reduce levels of anxiety and increase quality of life within 14 days.*
PEA helps improve mood through its ability to influence the endocannabinoid system, which is known to have an influence on mood and sleep.*
Enhance Sports Performance with Levagen®+
Pushing past your limits is necessary when wanting to adapt and beat your competition. Levagen®+ helps you push past your threshold by reducing lactic acid build up and decreasing fatigue.
Clinical studies have also found Levagen®+ to reduce muscle damage and stimulate growth of muscle tissue post-exercise, allowing individuals to reduce recovery time and enhance muscle adaptations.
How does it work?
PEA operates through multiple pathways and mechanisms within the body to provide its beneficial effects:
Directly
PEA reduces inflammation locally by binding on to PPAR-a receptors and inhibiting secretion of pro-inflammatory signalling molecules.
PEA enhances the levels and actions of other compounds that are anti-inflammatory and provide pain relief (1, 2). This mechanism is known as the ‘entourage effect’. PEA has a naturally low affinity for CB1 and CB2 receptors and only activates transient receptor potential vanilloid type-1 (TRPV1) channels when at very high concentrations in the body. TRPV1 channels are found on the outside of nerve cells and play a part in pain and temperature regulation (3).
Indirectly
To exert its beneficial effects. PEA can enhance the levels and actions of another endocannabinoid, anandamide, which is often dubbed as the ‘bliss’ molecule or the body’s own natural THC (the compound in cannabis that has psychoactive effects and produces a ‘high’). Anandamide has a profound analgesic response, before the pain signal even arrives at the spinal cord. The mode of action that PEA acts upon is by inhibiting the enzyme that degrades this molecule – Fatty Acid Amide Hydrolaze (FAAH). Anandamide act upon CB1 and CB2 receptors and TRPV1 channels, helping to combat pain and increase relaxation (4, 5, 6).
